|
WELCOME
TO
Faster
Growing Hair
The site
for people who want longer hair.
HOME
Contact
Us
Sunset Marketing
Attn: Hair Formula 37
554 Green Tree Cove suite 201
Collierville, TN 38017
888-849-8686
Toll Free |
Hair Formula
37™
In Depth hair Growth
/ Nutritional Information
A period of organogenesis
follows during which an entirely new hair root is regenerated and the production
of a hair is resumed. The cycles of growth of each follicle consist of
the building up and tearing down of the structure. After a period of rest
the follicle is built anew from raw materials and each hair follicle goes
through the identical processes. It is important to point out at this
point that many of the metabolic requirements of the cells of the hair
follicle must be met at this time or adequate and optimal hair growth will
not occur. This means that certain vitamins and minerals must be present
in adequate proportions or there will be faulty or nonexistent hair growth.
Amino
Acids
Abundant amino acids are
characteristic of those cells of the hair follicle that carry out appreciable
protein synthesis. Deoxyribonucleic acid (DNA) is found only in the nucleus
of the hair follicle cell. Like that of RNA, the content of DNA increases
in cells during division. An increase in DNA content appears to be indirectly
related to an increase in protein synthesis. For this reason, those nutritional
factors such as folic acid and B12 which are vital for synthesis of some
of the building blocks of nucleic acid must be included in and formula
for hair growth.
Secure
Online Ordering MINERALS
Flesch has reviewed the
effect of diet on hair growth and states that impaired growth or loss of
hair is a common and early nonspecific response to many nutritional deficiencies
in animals. Van Koetsveld has reviewed work on the influence of feeding
on the coats of animals. In actively growing cells of the hair follicle,
the glycogen content has been shown to be greatly increased . Very little
of the glycogen is present in resting follicles and Montagna assumes that
the glycogen in the outer root sheath of the follicle is the source of
the energy for protein synthesis during hair growth. For this reason, enzymes
related to glucose metabolism and glycogen build-up are very important
in hair growth and those minerals and vitamins used by the body as cofactors
must be present in adequate amounts.
Secure
Online Ordering ZINC
It has been known for many
years that in animals when there is zinc deficiency, the hair follicles
will atrophy. It has also been noted that there is a marked impairment
of DNA and protein synthesis in experimental animals whenever zinc deficiency
is present . And in fact, without DNA replication, growth and protein synthesis
are severely limited . Studies by Altmann , Shin and Tal have shown that
zinc influences the confirmation of nucleic acids. As previously mentioned,
without the proper formation of nucleic acids, the cell replication and
hence hair growth cannot occur normally. It has been shown in many species
that coarse and sparse growth of hair generally accompanies zinc deficiency.
Duncan's textbook of diseases of metabolism also points out the vital role
which zinc plays not only in protein synthesis but in certain enzymes including
carbonic anhydrase, malic dehydrogenase as well as lactic anglutamic dehydrogenasis.
Malic dehydrogenase is very active in the Krebs cycle and lactic dehydrogenase
is associated intimately with the glycolytic cycle. These enzymes are reviewed
extensively in Duncan. For all the above reason related to its action and
enzyme chemistry and protein synthesis, I recommend zinc as being a primary
or being the primary mineral present in your formula. I would recommend,
however, that when possible you utilize zinc gluconate or orotate as a
more easily absorbed salt than zinc sulfate. I have found through experience
that zinc sulfate occasionally will cause some gastrointestinal distress
whereas I have never seen it with the gluconate or the orotate salt of
zinc.
Secure
Online Ordering
COPPER
Copper deficiencies in experimental
animals have reduced the pigmentation of hair . According to Duncan , when
human copper deficiency is observed it is the result of limited intake,
inhibition of absorption or excessive loss of the metal. The importance
of copper in hair metabolism is pointed out quite well by Fell in his study
of copper content of human tissues and body fluids. Fell points out that
only two of the tissues in the body contain more copper than hair, mainly
liver and brain tissue. Beinert has shown that copper is present in the
enzyme cytochrome oxidase, along with iron. This particular enzyme is very
important in hydrogen transport mechanisms of respiration of the hair follicle
cell. Another very important enzyme present in hair follicle cells is tyrosinase,
present principally in the melanosomes of the skin and eye. This is an
enzyme which catalyzes a series of reactions resulting in the conversion
of tyrosine to melanin. This melanin is very important in certain types
of hair color. Absence of tyrosinase or of its function results in albinism
. You can see the importance, therefore, of copper in the metabolism of
the hair follicle. Another important function of copper has been shown
in experiments by Sieve . The graying of hair has been produced experimentally
by this investigator by a lack of copper along with folic
acid, pantothenic acid and PABA. While this particular experiment
did not demonstrate that deficiency of copper alone caused graying, it
certainly was suggested that copper deficiency plays an important factor
in some cases of graying of the hair. In the synthesis of hair protein,
the formation of disulfide bonds is very important for the integrity and
structure of the hair itself. Copper has been shown to play an important
catalytic role in the formation of these disulfide bonds . One demonstration
of this or the effects of this defect of copper deficiency can be found
in Menke's kinky hair syndrome which was described by Danks . In this particular
defect there is a marked change in the texture of the hair caused by copper
deficiency which can be corrected by the adequate addition of copper to
the patient. The basic defect found in the hair is an abnormality of the
hair shaft structure and increased virility of the hair. The serum copper
is decreased and the hair sulphydryl-disulfide ratio is increased. The
hairs appear similar to those found in the wool of copper deficient sheep
and the defect appears to be associated in these patients with a defect
in intestinal absorption of copper. It is postulated by Danks that copper
deficiencies in general might produce a similar problem. Another hair pigment
which is found in humans is called pheomelanin which appears to produce
the yellow red pigment found in hair. According to Flesch and Rothman and
Russell , this is also a tyrosinase dependent
pigment and requires copper for its action and its formation. It is postulated
that lack of adequate copper for an enzyme cofactor would produce defective
pigment formation in patients with yellow or red or combined coloring.
Mason also points out that zinc is required in addition to copper for part
of the chain of chemical reactions triggered by enzymes that finally produces
melanin or its derivatives.
Manganese
and Iron
I will cover manganese and iron
together in the same section since some of the enzyme reactions and some
of the biochemical pathways in which they are active are the same. Wacker
discusses nucleic acids and metals in his paper. It was found that chromium,
manganese, nickel, iron and other metals were present in RNA from diverse
biological sources, pointing out the importance of manganese and iron in
the synthesis of RNA. Prasad points out that manganese and iron are important
in the Kreb cycle. Without the presence of adequate amounts of these two
metals, the Kreb cycle of oxidative energy production cannot occur at optimal
levels. Isocitric dehydrogenase (IDH) which is a manganese dependent enzyme
and succinic dehydrogenase (SDH) which is an iron dependent enzyme are
two important links in the chain of the Kreb cycle. Without optimal function
of the Kreb cycle, adequate high energy phosphate bonds cannot be produced
and therefore adequate glycogen which is vital for follicle growth cannot
be built up to be used as energy at a later date. Histochemical studies
of the hair follicle by Montagna have shown how easily iron can be localized
in the hair follicle and how important it is, both in the oxidative and
hydrogen transport systems of the hair follicle. Incidentally, hydrogen
transport is the usual method by which cells oxidize materials. Instead
of direct addition of oxygen, hydrogen is removed which accomplishes the
same thing, mainly oxidation of a compound.
Iodine
Iodine intake of many persons
has been shown to be markedly deficient according to a study by Saxena
. Organic iodine such as found in kelp is better retained and less readily
lost in the urine than potassium iodide . In thyroid deficiency caused
by low iodine intake in certain experimental animals, there was loss of
hair as noted by Cuthbertson . This indicated the importance of an adequate
supply of iodine and its formation into thyroxine for hair growth to proceed
normally and at optimal levels. Thyroxine then stimulates a spontaneous
replacement of hair in intact and thyroid hormone deficient animals . The
cycle of growth remains normal regardless of how activity is initiated
in the follicle. The mechanism of thyroid action on hair growth is not
known, but it is believed that this may enhance the utilization of essential
nutrients by the follicle . Perhaps thyroxine stimulates the skin and hair
follicles directly and acts at the mydocondrial level of organization on
exidited enzyme systems.
Folic
Acid and B12
An adequate supply of nucleic
acids for formation of nucleo-proteins must be present at the hair follicle
site for adequate and healthy hair growth to occur. both folic acid and
vitamin B12 appear to be separately concerned with production of nucleic
acids . Some believe that vitamin B12 is concerned with the synthesis of
uracil, one of the building blocks of RNA and that folic acid converts
uracil to thiamine, which is found in the RNA as a very necessary component
. It has been noted that persons made deficient in folic acid often become
completely bald, but the hair grows in normally after the vitamin is given
. reference is made to the article by Sieve in which lack of folic acid
is one of the components which cause graying of hair with restoration to
its natural color when replacement therapy was given. A folic acid deficiency
prevents dozens of important physiological functions: interferes with the
utilization of sugar and amino acids, stops all cell division and healing,
and causes the hair, eyebrows and eyelashes to fall out . Almost all of
these functions are related to adequate and healthy hair growth. The folic
acid / tetrafolic acid system provides a unique mechanism for the reduction
of carbon to methyl that can be transferred to a methyl acceptor. This
is the explanation of the synthesis of choline, creatine and other methyl
containing metabolites in animals fed diets deficient in sources of preformed
methyl. Thus the folic acid / tetrafolic acid system is a vital part of
the metabolism of man and is very important in the synthesis of hair follicle
proteins and structural compounds. The folic acid / tetrafolic acid system
by reversed reactions also provides a mechanism for the addition of partially
oxidized carbon during the synthesis of serinen to such structures as the
purine and pyrimidine rings . Duncan has described folic acid deficiency
as possibly the most common vitamin deficiency in North America today.
Its prevalence seems to be on the increase and responsibility for this
at least in part rests on the exclusion of folic acid from many diets in
this country today. Many physicians hesitate to give folic acid and many
patients hesitate to take folic acid because of the fear that it might
correct the anemia of certain B12 deficiencies while allowing neurological
manifestations to progress. According to Duncan there may be many reasons
for the deficiency of folate including dietary lack, impaired absorption,
increased requirements, antagonism from drugs prescribed for patients and
lack of protection of folate coenzymes that is related to either vitamin
C or iron deficiency. Studies show that vitamin B12 is closely related
in function to four of the important amino acids or forms of protein, folic
acid, and pantothenic acid. Thus without vitamin B12, the function of the
nutritional elements may not be optimal . Duncan has also pointed out the
function of vitamin B12 in immediate reduction and isomerization reactions.
It is intimately related metabolically with folic acid. In this regard,
vitamin B12 can alter the reduction level of the single carbon units transferred
by folic acid coenzymes. It participates in the reduction of ribos to deoxy
ribos, converting uracil ribotide to uracil deoxyribotide prior to the
addition of a single carbon unit by folic acid coenzyme to form thiamine
deoxyribotide. In addition, vitamin B12 is an accessory to folic acid in
some transmethylation reactions and may be necessary for the activity of
folic acid conjugases. The conversion of methyl malonyl CoA to succinyl
CoA requires vitamin B12, and in the deficiency state, large amounts of
methyl malonylate are excreted in the urine. For all the reasons cited
above and to somewhat repeat myself, it is important for any actively growing
tissues such as the hair follicle to have adequate supplies of folic acid
and vitamin B12 present daily for optimal hair growth and for healthy hair
growth to occur.
Choline
and Inositol
Choline and inositol are also
very important for the metabolism of hair both in a direct and indirect
manner. It has been noted that thyroxine cannot be made without choline
and that rats become hairless if kept on diets low in inositol . Inositol
was mentioned in the Science Newsletter ( in 1956. It was stated there
that inositol was needed for growth and survival of cells and bone marrow,
eye membranes, embryos, gut and other rapidly growing tissues like hair
follicles. Inositol has been known to appear in human hair with speculation
as to its value in restoring color to gray hair. In the book "Inositol"
published by Corn Products Sales Company, Many observed physiological values
of inositol are listed. Choline is important in methylation reactions that
result in the formation of thiamines and thymydylic acids from uracil and
deoxyuridilic, respectively. Of great importance is the occurrence of additional
methylation reactions that are believed to occur after nucleatides are
built into polymeric, macro molecular nucleic acids . Changes in hair pigment
were produced by omission of choline or pantothenic acid from the diet
and Wooley showed the relationship of choline and inositol to growth of
hair in animal experiments. Engle (65) found inositol to be an essential
growth factor for normal cells including hair follicle cells. And Wooley
showed that spontaneous cure of alopecia (hair loss) in animals was dependent
on an adequate supply of inositol. In light of the apparently essential
role that choline and inositol play in the growth and proper nutrition
of hair cells, it would be certainly logical to include both of these important
compounds in any formula supplying the needs of the hair.
Secure
Online Ordering
Pantothenic
acid
and its calcium salt, calcium
pantothenate are also quite important in hair growth and in nutrition of
the actively growing hair follicle cells. As previously mentioned in a
paper by Owens changes in hair pigment were produced by omission of either
choline or pantothenic acid from the diet. Pantothenic acid was found by
Wooley to influence alopecia in animal experiments. Flesch has noted that
one of the deficiencies said to cause impaired hair growth is pantothenic
acid. Deficiency of pantothenic acid and riboflavin in black children not
only caused depigmentation, but made their hair grow straight . This deficiency
seems to be associated with the utilization of copper. The skin of rats
deficient in pantothenic acid may contain as much as five times the amount
of copper in normal skin, ie: the copper cannot be utilized and accumulates
. One can therefore see the complex relationship of the vitamins and minerals
to each other and to the proper growth of the hair follicle cells. Pantothenic
acid and inositol functions are related in that too little pantothenic
acid in the diet appears to disrupt the function of inositol . Rodell's
book on the vitamins gives a number of references to graying of hair and
paraminobenzoic acid and panthenol as well as the efficiency of unsaturated
fatty acids when adequate supplies of pantothenic acid are present. It
should be pointed out that where unsaturated fatty acid deficiencies are
present you may find dry skin, brittle, lusterless falling hair and dandruff.
Therefore, the pantothenic acid appears to have a rather protective effect
on these unsaturated fatty acids. Reference is also made by an article
in the British Medical Journal to restoration of color to gray hair using
pantothenic acid in certain experiments. Pantothenic acid functions and
is present in all living cells, mostly in the form of coenzyme A. CoA is
the cofactor of one of the most important enzymes of intermediate metabolism.
It is formed by joining pantothenic acid with other materials to form a
structure of coenzyme A. CoA activates acetate by converting it to an acetyl
CoA. The pivotal compound for many pathways. Duncan states that acetyl
CoA is concerned with #1 - acetylation of choline, aromatic amins and other
substances detoxified by acetylation; #2 - synthesis of fatty acids, acetoacetic
acid, cholesterol and styroids; and #3 - oxidation of pyruvate. For our
purposes in designing a formula which would help stimulate the metabolism
of the hair follicle, the third is the most important. In the metabolism
of glucose and other substances, pyruvate plays a pivotal role. In order
to enter the Kreb cycle and produce energy by oxidation it is necessary
to change pyruvate to acetate in order for the two carbon acetates to enter
the Kreb cycle. Without adequate supplies of coenzyme A this will be impossible
and the hair follicle nutrition will suffer. Therefore, it is an absolute
necessity that pantothenic acid be added to this formula. X. Paramino Benzoic
Acid (PABA) In the experiment by Sieve the lack of copper, folic acid,
pantothenic acid and PABA influences the intestinal bacteria so that they
can produce folic acid and folic acid in turn helps the body to assimilate
pantothenic acid. Ansbacher also seems to give corroboration to the theory
of the action of PABA and pantothenic acid in protecting the natural color
of the hair.
Niacin
Those preceding nutrients in
the B complex and niacin have been found to be very important in the nutrition
of various experimental animals and the vitamin B complex taken over long
periods has been found to restore human hair pigmentation . There was also
an article by Hudgins concerning the peripheral blood vessel dilating effect
of niacin which would include, of course, the blood vessels of the scalp.
Frost has noted that dietary deficiencies of certain vitamins can cause
achromotrichia (problems with hair color). Bullough has shown that there
is a known dependence of epidermal mycosis on the active respiration of
the epidermal cells. His experiments show that this was also similarly
dependent in the follicular matrix. Energy produced through the oxidation
of carbohydrates is the primary source of the energy necessary for synthesis
of hair cells or of hair in the follicle. Both in the oxidation of glucose
and glycogen and in the formation of glycogen from its precursors. This
is doubly important in the hair follicle cell since the synthetic potential
of the proliferating cells of the follicle bulb is high relative to that
of other tissues . In summary, certain vitamins, minerals and amino-acids
are crucial to the metabolic pathways involved in keratin protein metabolism.
Without the nutrients cited, the hair growth process will slow or cease.
Biotin
- helps in the formation of fatty acids, metabolism of amino acids,
and promotes healthy hair skin and nails.
L-Cysteine
- an amino acid which contains sulfur and functions as a building
block for all proteins
L-Tyrosine
- an amino acid when metabolized provides mellanin (hair color)
Methionine
- necessary for the sythesis of cysteine and taurine
B-Vitamins
- essential for hair grow
Vitamin
A - necessary for hair growth but mega doses may have a reverse
effect
Vitamin
E - necessary for hair growth but mega doses may have a reverse
effect
|
Have
short hair? Want Longer hair ...faster?
|
"...certain vitamins
and minerals must be present in adequate proportions or there will be faulty
or nonexistent hair growth..."
|
|